[Leu5]-Enkephalin, amide

CAS No. 60117-24-0

[Leu5]-Enkephalin, amide ( Leu-Enkephalin amide )

Catalog No. M29812 CAS No. 60117-24-0

[Leu5]-Enkephalin, amide is a δ opioid receptor agonist. Enkephalin, one of several naturally occurring morphinelike substances (endorphins) released from nerve endings of the central nervous system and the adrenal medulla.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    [Leu5]-Enkephalin, amide
  • Note
    Research use only, not for human use.
  • Brief Description
    [Leu5]-Enkephalin, amide is a δ opioid receptor agonist. Enkephalin, one of several naturally occurring morphinelike substances (endorphins) released from nerve endings of the central nervous system and the adrenal medulla.
  • Description
    [Leu5]-Enkephalin, amide is a δ opioid receptor agonist. Enkephalin, one of several naturally occurring morphinelike substances (endorphins) released from nerve endings of the central nervous system and the adrenal medulla. (In Vitro):[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.1 nM.(In Vivo):Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05).
  • Synonyms
    Leu-Enkephalin amide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    δ opioid receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    60117-24-0
  • Formula Weight
    554.6
  • Molecular Formula
    C28H38N6O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45.
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